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vol. 8 no. 392 ra87
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- Received March 25, 2015
- Accepted August 13, 2015
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Copyright © 2015, American Association for the Advancement of Science
Research ArticleCancer
The E3 ligase APC/CCdh1 promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth
- Juxiang Cao1,*,†,
- Xiangpeng Dai2,*,
- Lixin Wan2,*,
- Hongshen Wang1,3,
- Jinfang Zhang2,
- Philip S. Goff4,
- Elena V. Sviderskaya4,‡,
- Zhenyu Xuan5,
- Zhixiang Xu6,
- Xiaowei Xu7,
- Philip Hinds8,
- Keith T. Flaherty9,
- Douglas V. Faller10,
- Colin R. Goding11,
- Yongjun Wang3,§,
- Wenyi Wei2,§, and
- Rutao Cui1,3,§
- 1Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
- 2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
- 3Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.
- 4Molecular Cell Sciences Research Centre, Canadian Cancer Society Research Institute, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.
- 5Department of Molecular and Cell Biology, The University of Texas at Dallas, Dallas, TX 75080, USA.
- 6Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA.
- 7Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 8Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
- 9Cancer Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
- 10Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
- 11Ludwig Institute for Cancer Research, University of Oxford, Headington, Oxford OX3 7DQ, UK.
- ↵§Corresponding author. E-mail: yjwang88{at}hotmail.com (Y.W.); wwei{at}bidmc.harvard.edu (W.W.); rutaocui{at}bu.edu (R.C.)
↵* These authors contributed equally to this work.
↵† Present address: Division of Pulmonary and Critical Care Medicine and of Genetics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.
↵‡ Present address: Molecular Cell Sciences Research Centre, St. George’s, University of London, London SW17 0RE, UK.
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Science Signaling 01 Sep 2015:
Vol. 8, Issue 392, pp. ra87
DOI: 10.1126/scisignal.aab1995
Vol. 8, Issue 392, pp. ra87
DOI: 10.1126/scisignal.aab1995
Juxiang Cao
1Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
Xiangpeng Dai
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Lixin Wan
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Hongshen Wang
1Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
3Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.
Jinfang Zhang
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Philip S. Goff
4Molecular Cell Sciences Research Centre, Canadian Cancer Society Research Institute, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.
Elena V. Sviderskaya
4Molecular Cell Sciences Research Centre, Canadian Cancer Society Research Institute, St. George’s, University of London, Cranmer Terrace, London SW17 0RE, UK.
Zhenyu Xuan
5Department of Molecular and Cell Biology, The University of Texas at Dallas, Dallas, TX 75080, USA.
Zhixiang Xu
6Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35233, USA.
Xiaowei Xu
7Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Philip Hinds
8Department of Developmental, Molecular and Chemical Biology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Keith T. Flaherty
9Cancer Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
Douglas V. Faller
10Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
Colin R. Goding
11Ludwig Institute for Cancer Research, University of Oxford, Headington, Oxford OX3 7DQ, UK.
Yongjun Wang
3Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.
Wenyi Wei
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Rutao Cui
1Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA.
3Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.
