Research ArticlePlant biology

Inactivation of PYR/PYL/RCAR ABA receptors by tyrosine nitration may enable rapid inhibition of ABA signaling by nitric oxide in plants

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Science Signaling  01 Sep 2015:
Vol. 8, Issue 392, pp. ra89
DOI: 10.1126/scisignal.aaa7981

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NO more ABA activity

Abscisic acid (ABA) is a critical plant hormone, controlling developmental processes and immune responses. Long-term regulation of ABA signaling involves changes in gene expression that reduce ABA synthesis and enhance ABA metabolism. Castillo et al. found that various members of the ABA receptor PYR/PYL/RCAR family were modified posttranslationally by tyrosine nitration or S-nitrosylation at cysteine residues, two covalent modifications that can result from increased nitric oxide (NO). These NO-mediated modifications and polyubiquitylation, which target proteins for degradation, occurred in a complex, potentially interconnected, and receptor-specific pattern in plants overexpressing individual receptors. Tyrosine nitration, but not S-nitrosylation, inhibited ABA-induced activity in vitro, suggesting that tyrosine nitration may be a mechanism to rapidly tune the cellular responsiveness to ABA.

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