Research ArticleNeovascularization

SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth

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Science Signaling  22 Sep 2015:
Vol. 8, Issue 395, pp. ra94
DOI: 10.1126/scisignal.aaa8695

Halting blood vessel formation in the eye

Diabetics and preterm infants are susceptible to vision loss or blindness because of abnormal blood vessel formation in the eye, a process called retinal neovascularization. Using a model of this disease process, Sun et al. found that mice that lacked a protein called SOCS3 in the neurons and glial cells of the eye had greater retinal neovascularization than did control mice. Their results suggest that SOCS3 prevents neurons and glial cells from releasing too much VEGF (a cytokine that promotes blood vessel formation) by inhibiting the transcription factor STAT3, which can trigger the production of VEGF.

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