Synapse and genome: An elusive tête-à-tête

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Science Signaling  29 Sep 2015:
Vol. 8, Issue 396, pp. pe2
DOI: 10.1126/scisignal.aad2441


  • Fig. 1

    LTP/LTD and mCG have been in the spotlight for so long that researchers may be missing contributions from other important factors, such as non-Hebbian plasticity mechanisms and 5hmC. Notably, LTP/LTD readouts provide synapse-specific information, but homeostatic mechanisms alter the cell more widely in keeping with the likely effects of changes in transcription. For the most part, BDNF expression has been the main genomic target used to assess plasticity, but there are likely many other important genes worthy of inclusion under a wider spotlight.


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