Contents

Contents

• Research Articles

  • The Golgi apparatus is a functionally distinct Ca²⁺ store regulated by the PKA and Epac branches of the β₁-adrenergic signaling pathway

    By Zhaokang Yang, Hannah M. Kirton, David A. MacDougall, John P. Boyle, James Deuchars, Brenda Frater, Sreenivasan Ponnambalam, Matthew E. Hardy, Edward White, Sarah C. Calaghan, Chris Peers, Derek S. Steele

    Science Signaling13 Oct 2015 : ra101 Full AccessRestricted Access

    Calcium released from the Golgi apparatus may promote receptor trafficking to the surface of cardiomyocytes.

    • Editor's Summary
    • Abstract
    • Full Text
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  • Frontrunners of T cell activation: Initial, localized Ca²⁺ signals mediated by NAADP and the type 1 ryanodine receptor

    By Insa M. A. Wolf, Björn-Philipp Diercks, Ellen Gattkowski, Frederik Czarniak, Jan Kempski, René Werner, Daniel Schetelig, Hans-Willi Mittrücker, Valéa Schumacher, Manuel von Osten, Dimitri Lodygin, Alexander Flügel, Ralf Fliegert, Andreas H. Guse

    Science Signaling13 Oct 2015 : ra102 Full AccessRestricted Access

    High-resolution imaging of live T cells characterizes the early Ca²⁺ signals required for T cell activation.

    • Editor's Summary
    • Abstract
    • Full Text
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• Research Resource

  • Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells

    By Scott F. Rusin, Kate A. Schlosser, Mark E. Adamo, Arminja N. Kettenbach

    Science Signaling13 Oct 2015 : rs12 Full AccessRestricted Access

    Proteomics and bioinformatics reveal a role for the phosphatase PP6 in opposing phosphorylation by casein kinase 2.

    • Editor's Summary
    • Abstract
    • Full Text
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• Editors' Choice

  • EGFR deploys its own defense

    By Leslie K. Ferrarelli

    Science Signaling13 Oct 2015 : ec289 Full AccessRestricted Access

    Activation of the tyrosine kinase receptor EGFR promotes the secretion of a metalloprotease that degrades an extracellular antagonist.

    • Abstract

  • Leaving a lasting impression

    By Wei Wong

    Science Signaling13 Oct 2015 : ec290 Full AccessRestricted Access

    Mesenchymal stem cells can use Fas delivered by exosomes to trigger long-lasting changes in epigenetic programming.

    • Abstract

  • Cancer as a case of uncontrolled traffic

    By Paula A. Kiberstis

    Science Signaling13 Oct 2015 : ec291 Full AccessRestricted Access

    Mutations that disrupt protein trafficking can contribute to cancer development.

    • Abstract

  • The pain is mostly in the brain

    By Katrina L. Kelner

    Science Signaling13 Oct 2015 : ec292 Full AccessRestricted Access

    PACAP-38–mediated delayed activation and sensitization of central trigeminovascular neurons may contribute to migraines.

    • Abstract

  • Striga uses a hypersensitive receptor

    By Pamela J. Hines

    Science Signaling13 Oct 2015 : ec293 Full AccessRestricted Access

    Features of the ligand-binding pocket explain how a parasitic plant receptor is exquisitely sensitive to host plant hormones.

    • Abstract

  • Orchestrating a viral takeover

    By Kristen L. Mueller

    Science Signaling13 Oct 2015 : ec294 Full AccessRestricted Access

    Elevated amounts of a viral noncoding RNA that suppresses host immunity likely led to an outbreak of dengue virus.

    • Abstract

  • Another strike against antioxidants

    By Yevgeniya Nusinovich

    Science Signaling13 Oct 2015 : ec295 Full AccessRestricted Access

    Antioxidants increase migration and invasion of human melanoma cells and accelerate metastasis in an endogenous mouse model of malignant melanoma.

    • Abstract