Contents
Vol 8, Issue 398
Contents
Research Articles
- The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway
Calcium released from the Golgi apparatus may promote receptor trafficking to the surface of cardiomyocytes.
- Frontrunners of T cell activation: Initial, localized Ca2+ signals mediated by NAADP and the type 1 ryanodine receptor
High-resolution imaging of live T cells characterizes the early Ca2+ signals required for T cell activation.
Research Resource
- Quantitative phosphoproteomics reveals new roles for the protein phosphatase PP6 in mitotic cells
Proteomics and bioinformatics reveal a role for the phosphatase PP6 in opposing phosphorylation by casein kinase 2.
Editors' Choice
- EGFR deploys its own defense
Activation of the tyrosine kinase receptor EGFR promotes the secretion of a metalloprotease that degrades an extracellular antagonist.
- Leaving a lasting impression
Mesenchymal stem cells can use Fas delivered by exosomes to trigger long-lasting changes in epigenetic programming.
- Cancer as a case of uncontrolled traffic
Mutations that disrupt protein trafficking can contribute to cancer development.
- The pain is mostly in the brain
PACAP-38–mediated delayed activation and sensitization of central trigeminovascular neurons may contribute to migraines.
- Striga uses a hypersensitive receptor
Features of the ligand-binding pocket explain how a parasitic plant receptor is exquisitely sensitive to host plant hormones.
- Orchestrating a viral takeover
Elevated amounts of a viral noncoding RNA that suppresses host immunity likely led to an outbreak of dengue virus.
- Another strike against antioxidants
Antioxidants increase migration and invasion of human melanoma cells and accelerate metastasis in an endogenous mouse model of malignant melanoma.
About The Cover

Online Cover This week features a Research Resource that uses proteomic analysis to identify potential substrates and regulatory events dependent on the phosphatase PP6 in dividing cells. The image shows a cell with normally condensed chromosomes and hypercondensed chromosomes. [Image: Scott Rusin, Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA]