Research ArticleCell Biology

The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway

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Sci. Signal.  13 Oct 2015:
Vol. 8, Issue 398, pp. ra101
DOI: 10.1126/scisignal.aaa7677

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A distinct calcium store in cardiomyocytes

In cardiomyocytes, contraction can be triggered by large influxes of calcium (Ca2+) into the cytoplasm from the sarcoplasmic reticulum. Yang et al. found that Ca2+ released from the Golgi apparatus had a distinct function from the Ca2+ stored in the sarcoplasmic reticulum. Instead of triggering contraction, Golgi-released Ca2+ promoted the trafficking of a receptor to the surface of cardiomyocytes. The adrenaline receptor β1-AR enhanced the release of Ca2+ from the Golgi through a process involving two pathways downstream of the second messenger cAMP. Cardiomyocytes from rats with experimentally induced heart failure showed increased release of Ca2+ from the Golgi, which was associated with decreased abundance of phosphodiesterases in the PDE3 and PDE4 families, which degrade cAMP. Thus, the Golgi apparatus releases Ca2+ in response to changes in cAMP concentrations, such as those that occur during adrenergic stimulation or heart failure.