Contents
20 October 2015
Vol 8, Issue 399
Vol 8, Issue 399
Contents
Research Articles
- Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis
Disruption of voltage-gated calcium channels in thymocytes inhibits T cell development in mice.
- CD4+ T cell–dependent and CD4+ T cell–independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals
Mathematical analysis of the cytokine secretion profiles of collections of patient immune cells uncovers network-level effects of HIV infection.
- Abnormal mechanosensing and cofilin activation promote the progression of ascending aortic aneurysms in mice
Aortic aneurysms may form when smooth muscle cells cannot respond appropriately to external mechanical forces.
Review
- Matters of context guide future research in TGFβ superfamily signaling
The rich contextual nature of TGFβ signaling output offers clues for future therapeutic strategies.
Editors' Choice
- Understanding empathy
An opioid antagonist blocks both placebo-induced analgesia and placebo-induced reduction in empathy for pain of another.
- Finding the good in malaria
A protein isolated from malaria enables drugs to home in on tumor cells.
- Lipids and microbes get inflammatory
Saturated lipids increase inflammation in white adipose tissue through effects on gut microbiota.
- Hedgehog stimulates polyamine biosynthesis
Hedgehog signaling promotes neural proliferation by stimulating the biosynthesis of polyamines through a noncanonical mechanism.
- Keeping a leash on cancer-killing cells
Cancer-targeted T cells get a fail-safe control mechanism.
- Dying to impress the immune system
Active signaling in dying cells determines their immunogenicity.
- How T cells maintain their identity
Regulatory T cells require the transcription factor Helios to stably maintain their identity.
- Changes over time build neuronal diversity
Neuronal progenitors themselves change during development, even while continuing to generate new neurons.
- A tripartite gene silencing complex
The structure of a gene silencing complex reveals how it self-activates and is inhibited by a cancer-associated chromatin mutation.
- GPR3, a therapeutic target for AD?
In mouse models of Alzheimer’s disease, loss of GPR3 reduces symptoms.
- A new peptide for treating retinal disease
A stable small peptide that binds to two retinal VEGF receptors blocks angiogenesis in animal models of human retinal diseases.
About The Cover
Online Cover This week features a Research Article that highlights how mathematical analysis of the cytokine secretion profiles of mixed populations of immune cells from HIV-infected patients uncovered defects in distinct immune cells that affected the network level of the immune response. The computer-generated image depicts a cluster of HIV particles. [Image: Science Picture Co/Science Source]