Matters of context guide future research in TGFβ superfamily signaling

See allHide authors and affiliations

Science Signaling  20 Oct 2015:
Vol. 8, Issue 399, pp. re10
DOI: 10.1126/scisignal.aad0416


The molecular mechanisms underlying the renowned context dependency of TGFβ signaling output remain an active and often confounding area of research. This review, which contains four figures, one table, a movie, and 119 references, describes the current discoveries and future directions in the rich field of TGFβ signaling in physiology and disease.


The highly conserved wiring of the SMAD-dependent transforming growth factor β (TGFβ) superfamily signaling pathway has been mapped over the last 20 years after molecular discovery of its component parts. Numerous alternative TGFβ-activated signaling pathways that elicit SMAD-independent biological responses also exist. However, the molecular mechanisms responsible for the renowned context dependency of TGFβ signaling output remains an active and often confounding area of research, providing a prototype relevant to regulation of other signaling pathways. Highlighting discoveries presented at the 9th FASEB meeting, The TGFβ Superfamily: Signaling in Development and Disease (July 12–17th 2015 in Snowmass, Colorado), this Review outlines research into the rich contextual nature of TGFβ signaling output and offers clues for therapeutic advances.

View Full Text

Stay Connected to Science Signaling