Editors' ChoiceHost-Microbe Interactions

The benefits of Escherichia coli

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Science Signaling  03 Nov 2015:
Vol. 8, Issue 401, pp. ec326
DOI: 10.1126/scisignal.aad7728

Infection and intestinal damage can trigger severe muscle wasting and loss of fat in mice. How this happens is poorly understood. Palaferri Schieber et al. discovered a protective Escherichia coli strain in their mouse colony. Mice intestinally colonized with the E. coli and infected with the food-poisoning bug Salmonella or with the lung pathogen Burkholderia did not waste away. Without the E. coli, similarly infected mice became fatally ill. The protective E. coli stimulated an innate immune mechanism that ensured that muscle-signaling pathways were not damaged by infection. Thus, the friendly E. coli allowed its host to tolerate and survive the pathogens.

A. M. Palaferri Schieber, Y. M. Lee, M. W. Chang, M. Leblanc, B. Collins, M. Downes, R. M. Evans, J. S. Ayres, Disease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling. Science 350, 558–563 (2015). [Abstract] [Full Text]

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