Research ArticlesMUSCLE BIOLOGY

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

See allHide authors and affiliations

Science Signaling  10 Nov 2015:
Vol. 8, Issue 402, pp. ra113
DOI: 10.1126/scisignal.aab3715

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Thinner with FGF21

Skeletal muscle alters whole-body metabolism through the release of hormones into the bloodstream called myokines. Guridi et al. found that skeletal muscle released a hormone called FGF21 in mice with skeletal muscle–specific activation of mTORC1, a protein complex that links nutrient availability to cell growth. Compared to control mice, these mice weighed less, likely because of increased fatty acid oxidation and increased energy expenditure, and had lower plasma concentrations of glucose and insulin. Systemic administration of antibodies directed against FGF21 reversed these metabolic changes. Thus, FGF21 released from skeletal muscle can mediate changes in whole-body metabolism.

View Full Text

Stay Connected to Science Signaling