Research ArticleCytokine Signaling

Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency

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Science Signaling  10 Nov 2015:
Vol. 8, Issue 402, pp. ra114
DOI: 10.1126/scisignal.aab2677

Modeling cytokine behavior

The use of cytokines, such as interleukin-2 (IL-2) or IL-13, as therapies has been hampered by the fact that many cytokines share receptor subunits on different cell types. Moraga et al. generated recombinant variants of IL-13 with a wide range of binding affinities for the IL-13 receptor. Mathematical modeling of the correlation between the receptor binding affinities of the variants and the extents to which they differentially stimulated early and late cellular responses highlighted aspects of receptor-ligand binding properties that should aid in the development of more effective cytokine therapies.

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