Research ArticleGPCR SIGNALING

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

See allHide authors and affiliations

Science Signaling  10 Nov 2015:
Vol. 8, Issue 402, pp. ra115
DOI: 10.1126/scisignal.aad0872

Receptor methylation controls behavior

D2 dopamine receptors are targeted by antipsychotic agents to regulate behavior. Likhite et al. found putative arginine methylation motifs in some human G protein–coupled receptors (GPCRs), including the D2 dopamine receptor, and in homologs in the worm Caenorhabditis elegans. The protein arginine methyltransferase PRMT5 methylated D2 in vitro, and preventing this modification inhibited D2 receptor signaling in cultured cells. C. elegans lacking prmt-5 exhibited behavioral problems similar to those of worms deficient in the D2-like receptor DOP-3. This study not only shows that methylation modulates GPCR signaling but also suggests that this modification may be important for clinically relevant targets like the D2 receptor.

View Full Text

Stay Connected to Science Signaling