The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

Neah Likhite; Christopher A. Jackson; Mao-Shih Liang; Michelle C. Krzyzanowski; Pedro Lei; Jordan F. Wood; Barbara Birkaya; Kerry L. Michaels; Stelios T. Andreadis; Stewart D. Clark; Michael C. Yu; Denise M. Ferkey

doi:10.1126/scisignal.aad0872

Research ArticleGPCR SIGNALING

The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling

Neah Likhite¹,
Christopher A. Jackson¹,
Mao-Shih Liang²,
Michelle C. Krzyzanowski¹,
Pedro Lei²,
Jordan F. Wood¹,
Barbara Birkaya¹,*,
Kerry L. Michaels¹,†,
Stelios T. Andreadis²,
Stewart D. Clark³,⁴,⁵,
Michael C. Yu¹,‡, and
Denise M. Ferkey¹,‡

¹Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
²Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.
³Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
⁴Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
⁵Research Institute on Addictions, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.

↵‡Corresponding author. E-mail: dmferkey{at}buffalo.edu (D.M.F.); mcyu{at}buffalo.edu (M.C.Y.)

↵* Present address: Department of Pathology and Anatomical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
↵† Present address: Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.

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Science Signaling 10 Nov 2015:
Vol. 8, Issue 402, pp. ra115
DOI: 10.1126/scisignal.aad0872

Neah Likhite

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Christopher A. Jackson

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Mao-Shih Liang

2Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Michelle C. Krzyzanowski

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Pedro Lei

2Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Jordan F. Wood

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Barbara Birkaya

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Kerry L. Michaels

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Stelios T. Andreadis

2Bioengineering Laboratory, Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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Stewart D. Clark

3Department of Pharmacology and Toxicology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.

4Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.

5Research Institute on Addictions, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.

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Michael C. Yu

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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For correspondence: dmferkey@buffalo.edu mcyu@buffalo.edu

Denise M. Ferkey

1Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

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For correspondence: dmferkey@buffalo.edu mcyu@buffalo.edu

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