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Science Signaling  24 Nov 2015:
Vol. 8, Issue 404, pp. ec354
DOI: 10.1126/scisignal.aad9095

The mammalian spinal cord coordinates neuronal systems across the body. Axons that cross the spinal cord midline during development first need permission to cross and then instruction not to keep crossing back and forth. Jaworski et al. studied the axonal guidance receptor ROBO3 and found a ligand NELL2 in mice that appears to help in this process.

A. Jaworski, I. Tom, R. K. Tong, H. K. Gildea, A. W. Koch, L. C. Gonzalez, M. Tessier-Lavigne, Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. Science 350, 961–965 (2015). [Abstract] [Full Text]