Research ArticleHost-Pathogen Interactions

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

See allHide authors and affiliations

Science Signaling  08 Dec 2015:
Vol. 8, Issue 406, pp. ra126
DOI: 10.1126/scisignal.aab3183

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Targets foreign and domestic

The cytosolic protein RIG-I (retinoic acid–inducible gene I) is a sensor of viral RNA, and its activation induces the host’s antiviral response. Ingle et al. found that infection of various human and mouse cells with RNA viruses, including the H5N1 influenza virus, resulted in the increased production of the microRNA miR-485, which targeted RIG-I mRNA for degradation. As a result, antiviral signaling was inhibited and viral replication was enhanced. However, when cells were exposed to increased amounts of virus, mir-485 was expressed, but viral replication was inhibited. Under these conditions, miR-485 targeted PB1 mRNA, which is a viral transcript required for H5N1 replication. Together, these data suggest that miR-485 exhibits bispecificity, with the extent of infection determining its target.