Contents
15 December 2015
Vol 8, Issue 407
Vol 8, Issue 407
Contents
Research Articles
- Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism
Body weight is regulated by posttranslational regulation of an mRNA encoding an adipokine that promotes lipolysis in adipocytes.
- Depletion of H2S during obesity enhances store-operated Ca2+ entry in adipose tissue macrophages to increase cytokine production
The gaseous signaling molecule H2S limits inflammation in adipose tissue by suppressing calcium signaling in resident macrophages.
- Network-level effects of kinase inhibitors modulate TNF-α–induced apoptosis in the intestinal epithelium
Network rewiring converts a survival-promoting kinase into a deadly one.
Podcast
- Science Signaling Podcast for 15 December 2015: Hydrogen sulfide and inflammation in obesity
The gaseous signaling molecule H2S suppresses calcium signaling in adipose tissue macrophages to limit inflammation.
Editors' Choice
- Protecting a guidance receptor from cleavage
The transmembrane protein Lrig2 prevents premature shedding of the ectodomain of the guidance receptor Neogenin.
- Signals from glia to neurons
FGF2 released by NG2 glia and D-serine released by astrocytes regulate glutamatergic circuits.
- Unsilencing antitumor T cell activity
The suppressor of cytokine signaling protein Cish inhibits T cell receptor signaling to suppress the antitumor activity of cytotoxic T cells.
- To be parasitic or symbiotic?
Rhizobial strains with HrrP degrade host-derived signaling peptides to become parasitic.
- Anti-inflammatory strategies reach for the SKY
The peptide SKY disrupts the interaction between the peptide HNP1 and the chemokine CCL5 on platelets, thereby reducing inflammation.
- OutRANKing osteosarcoma
Denosumab, an antibody targeting RANKL, is effective against osteosarcoma in mouse models.
- Aging: All in the head—and the gut
Two life-span–extending pathways in the worm converge to increase production of an enzyme in the intestine.
- Altering timing perturbs cell signaling
A signaling pathway is vulnerable to disruption by suitably timed input.
- Getting all stressed out by vitamin C
Cancer cells with certain mutations take up the oxidized form of vitamin C, which fatally disrupts their metabolism.
About The Cover
Online Cover This week features a Research Article that shows that the adipose tissue of obese mice contains reduced amounts of the gaseous signaling molecule hydrogen sulfide, which leads to increased production of proinflammatory cytokines by adipose tissue macrophages. However, in lean mice, hydrogen sulfide is more abundant and it suppresses calcium signaling in macrophages to limit cytokine production and inflammation. The image illustrates resident macrophages (red) in adipose tissue. [Image: K. Sutliff/Science Signaling]