Science Signaling Podcast for 15 December 2015: Hydrogen sulfide and inflammation in obesity

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Science Signaling  15 Dec 2015:
Vol. 8, Issue 407, pp. pc30
DOI: 10.1126/scisignal.aad9179

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This Podcast features an interview with Carl White, author of a Research Article that appears in the 15 December 2015 issue of Science Signaling, about how reduced bioavailability of hydrogen sulfide stimulates inflammation. In addition to altering metabolism, obesity also stimulates adipose tissue macrophages (ATMs) to secrete inflammatory cytokines into the circulation, which causes chronic systemic inflammation. Velmurugan et al. found that, compared to ATMs from lean mice, ATMs from obese mice were depleted of the gaseous signaling molecule hydrogen sulfide (H2S) and that bacterial lipopolysaccharide also reduced the amount of H2S in macrophages. H2S inhibited Orai3, a component of the store-operated Ca2+ entry (SOCE) pathway, in macrophages. Depletion of H2S disinhibited Orai3, leading to increased Ca2+ entry into macrophages and increased inflammatory cytokine production. Thus, the proinflammatory environment of adipose tissue is associated with the depletion of H2S in ATMs, which exacerbates inflammation by increasing SOCE in these cells.

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