Contents
22 December 2015
Vol 8, Issue 408
Vol 8, Issue 408
Contents
Editorial Guide
- The computable cell: A step toward personalized medicine
Generating and cataloging quantitative data for a reference cell is the first step toward computational prediction for individualized therapy.
Focus
- Beyond static biomarkers—The dynamic response potential of signaling networks as an alternate biomarker?
Properties from simulated pathway dynamics effectively predict neuroblastoma patient outcome.
Research Articles
- Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients
Patient-specific modeling of a cell death–promoting pathway may lead to personalized treatment strategies.
- A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca2+ permeation and SOCE-induced gene transcription
A special region of the store-operated calcium channel maintains channel function under conditions of low extracellular calcium.
Editors' Choice
- How stress can overcome latency
JNK signaling alters chromatin to induce reactivation of latent herpes simplex virus.
- Guiding vessels in the developing brain
Communication between neuroepithelial cells and endothelial cells, involving integrins, TGF-β, and neuropilin 1, controls vascular development in the brain.
- BMP2 decides cancer cell fate
BMP2 promotes growth of ovarian cancer stem cells selectively.
- A psoriatic switch
Implantable designer cells sense proinflammatory cytokines and produce anti-inflammatory molecules that attenuate psoriasis in mice.
- Inhibition of casein kinase 1δ reduces breast cancer
Casein kinase 1δ promotes breast tumorigenesis by activation of β-catenin.
- A channel involved in pain perception
Structural studies give insight into how a human sodium channel involved in pain perception can be selectively inhibited.
- A complex channel comes into focus
A cryo–electron microscopy structure provides a framework for understanding function and disease mechanisms in a family of calcium channels.
- Plants respond to smoke and fungi
Similar types of receptors enable plant and fungi symbiosis, as well as plant growth after a forest fire.
About The Cover
Online Cover This week features a Research Article that describes a calcium-accumulating region in Orai channels that is important for ion flux at low concentrations of extracellular calcium. The image shows a snapshot of a molecular dynamics simulation of this region of the channel. The yellow balls are calcium ions. [Image: Vasilina Zayats/Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, and Faculty of Sciences, University of South Bohemia, Czech Republic]