Contents
Vol 9, Issue 409
Contents
Editorial Guide
- 2015: Signaling Breakthroughs of the Year
Signaling research advances aid in understanding cellular and organismal regulation, as well as having biomedical, agricultural, and industrial implications.
Research Articles
- Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator
Plants release rosmarinic acid, which mimics bacterial quorum-sensing signals, to interfere with bacterial communication.
- Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis
Sequestration of aggregated proteins by p62 prevents macrophages from exacerbating atherosclerosis.
- Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use
Comparative analysis of mouse and human macrophages reveals conserved and species-specific use of Toll-like receptor signaling components.
Podcast
- Science Signaling Podcast for 5 January 2016: New directions in signaling research
Science Signaling editors discuss the current state of signal transduction research and the journal's place in this dynamic landscape.
Editors' Choice
- Impairing cognition with TNF-α
Hippocampal astrocytes stimulated by TNF-α contribute to cognitive defects.
- Allosteric regulation of Warts
Hippo pathway regulators allosterically switch the conformation of the kinase Warts.
- Reprogramming lipid metabolism to boost antiviral responses
Changes in cholesterol biosynthetic flux affect the sensitivity of an antiviral immune pathway.
- Papers of note in Science Translational Medicine
This week’s articles feature insights into TRP channels in preterm labor and an antibody treatment for diabetes.
- Papers of note in Science
Three articles provide insights into a protein complex that enables cells to sense leucine and regulate metabolism.
About The Cover

Online Cover This week features a Research Article that describes how the protein p62 enables macrophages to sequester aggregated proteins, thereby preventing these immune cells from exacerbating atherosclerosis. The image shows an aortic root section from a mouse model of atherosclerosis, with nuclei in blue, macrophages in turquoise, p62 in red, and polyubiquitinated proteins in green. [Image: Ismail Sergin/Washington University School of Medicine, St. Louis, MO]