Contents

Contents

• Editorial Guide

  • 2015: Signaling Breakthroughs of the Year

    By Elizabeth M. Adler

    Sci. Signal.05 Jan 2016 : eg1 Full AccessRestricted Access

    Signaling research advances aid in understanding cellular and organismal regulation, as well as having biomedical, agricultural, and industrial implications.

    • Abstract
    • Full Text
    • PDF

• Research Articles

  • Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator

    By Andrés Corral-Lugo, Abdelali Daddaoua, Alvaro Ortega, Manuel Espinosa-Urgel, Tino Krell

    Sci. Signal.05 Jan 2016 : ra1 Full AccessRestricted Access

    Plants release rosmarinic acid, which mimics bacterial quorum-sensing signals, to interfere with bacterial communication.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis

    By Ismail Sergin, Somashubhra Bhattacharya, Roy Emanuel, Emel Esen, Carl J. Stokes, Trent D. Evans, Batool Arif, John A. Curci, Babak Razani

    Sci. Signal.05 Jan 2016 : ra2 Full AccessRestricted Access

    Sequestration of aggregated proteins by p62 prevents macrophages from exacerbating atherosclerosis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use

    By Jing Sun, Ning Li, Kyu-Seon Oh, Bhaskar Dutta, Sharat J. Vayttaden, Bin Lin, Thomas S. Ebert, Dominic De Nardo, Joie Davis, Rustam Bagirzadeh, Nicolas W. Lounsbury, Chandrashekhar Pasare, Eicke Latz, Veit Hornung, Iain D. C. Fraser

    Sci. Signal.05 Jan 2016 : ra3 Full AccessRestricted Access

    Comparative analysis of mouse and human macrophages reveals conserved and species-specific use of Toll-like receptor signaling components.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast for 5 January 2016: New directions in signaling research

    By Michael B. Yaffe, Nancy R. Gough, Annalisa M. VanHook

    Sci. Signal.05 Jan 2016 : pc1 Full AccessRestricted Access

    Science Signaling editors discuss the current state of signal transduction research and the journal's place in this dynamic landscape.

    • Abstract
    • Full Text

• Editors' Choice

  • Impairing cognition with TNF-α

    By Nancy R. Gough

    Sci. Signal.05 Jan 2016 : ec1 Full AccessRestricted Access

    Hippocampal astrocytes stimulated by TNF-α contribute to cognitive defects.

    • Abstract

  • Allosteric regulation of Warts

    By Annalisa M. VanHook

    Sci. Signal.05 Jan 2016 : ec2 Full AccessRestricted Access

    Hippo pathway regulators allosterically switch the conformation of the kinase Warts.

    • Abstract

  • Reprogramming lipid metabolism to boost antiviral responses

    By Wei Wong

    Sci. Signal.05 Jan 2016 : ec3 Full AccessRestricted Access

    Changes in cholesterol biosynthetic flux affect the sensitivity of an antiviral immune pathway.

    • Abstract

  • Papers of note in Science Translational Medicine

    By Nancy R. Gough

    Sci. Signal.05 Jan 2016 : ec4 Full AccessRestricted Access

    This week’s articles feature insights into TRP channels in preterm labor and an antibody treatment for diabetes.

    • Abstract

  • Papers of note in Science

    By Nancy R. Gough

    Sci. Signal.05 Jan 2016 : ec5 Full AccessRestricted Access

    Three articles provide insights into a protein complex that enables cells to sense leucine and regulate metabolism.

    • Abstract