Research ArticleSystems Immunology

Coordinate actions of innate immune responses oppose those of the adaptive immune system during Salmonella infection of mice

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Science Signaling  12 Jan 2016:
Vol. 9, Issue 410, pp. ra4
DOI: 10.1126/scisignal.aaa9303

Assembling the immune system jigsaw

Analysis of individual components of the immune response to infection solves only small parts of the immune system puzzle. Hotson et al. analyzed the variable immune responses of Salmonella-infected mice over time by measuring the numbers and signaling states of multiple immune cell types and combining these data with measurements of serum cytokine concentrations, antibody responses, and bacterial burden. Mathematical analysis of this multiparametric data set revealed response elements that clustered together into patterns that showed how different components of the immune system interacted with each other. For example, neutrophils inhibited the functions of B cells during the course of infection. Thus, this systems biology approach enables the assembly of interconnected sections of the immune system puzzle.

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