Editors' ChoiceCell Biology

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Science Signaling  09 Feb 2016:
Vol. 9, Issue 414, pp. ec29
DOI: 10.1126/scisignal.aaf4223

Stem Cells

Quiescent and aging hair follicle stem cells

DNA damage triggers the destruction of type XVII collagen, resulting in hair follicle stem cell depletion and hair loss.

H. Matsumura, Y. Mohri, N. T. Binh, H. Morinaga, M. Fukuda, M. Ito, S. Kurata, J. Hoeijmakers, E. K. Nishimura, Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science 351, aad4395 (2016). [Abstract]

Dynamic expression of a transcription factor sustains the quiescent cellular state in activated hair follicle stem cells during self-renewal.

L. Wang, J. A. Siegenthaler, R. D. Dowell, R. Yi, Foxc1 reinforces quiescence in self-renewing hair follicle stem cells. Science 351, 613–617 (2016). [Abstract]

M. Lei, C.-M. Chuong, Aging, alopecia, and stem cells. Science 351, 559–560 (2016). [Abstract]

Cancer Therapeutics

Cancer therapy by entrapment

A surprising mechanistic insight may lead to drugs targeting an oncogenic form of KRAS expressed in lung cancer.

P. Lito, M. Solomon, L.-S. Li, R. Hansen, N. Rosen, Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism. Science 351, 604–608 (2016). [Abstract]

Scientific Community


A Nobel laureate's work on G proteins illuminated how signals are transmitted into cells.

M. Simon, Alfred Gilman (1941–2015). Science 351, 566 (2016). [Abstract]

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