PodcastCancer Biology

Science Signaling Podcast for 9 February 2016: Transendothelial migration

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Science Signaling  09 Feb 2016:
Vol. 9, Issue 414, pp. pc4
DOI: 10.1126/scisignal.aaf3023

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This Podcast features an interview with Claus Jørgensen, author of a Research Article that appears in the 9 February 2016 issue of Science Signaling, about his group's innovative approach for identifying signaling events that are important for the transendothelial migration of cancer cells. Cancer cells can metastasize by traveling through the circulatory system. Extravasation, the process of exiting a blood vessel, requires that circulating cancer cells adhere to the endothelial sheet, then migrate across the endothelium. Locard-Paulet et al. developed an in vitro model of transendothelial migration using metastatic breast cancer cells and umbilical vein endothelial cells that had been labeled prior to coculturing so that isolated proteins could be assigned to one cell type or the other. Phosphoproteomic analysis of extracts from cocultured cells identified signaling events required in each cell type for transendothelial migration.

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