Contents
16 February 2016
Vol 9, Issue 415
Vol 9, Issue 415
Contents
Editorial Guide
- Focus Issue: Cell biology meets cancer therapy
Newly discovered druggable targets and mechanisms of action for available drugs reveal new ways to kill cancer cells and personalize therapy.
Research Articles
- ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies
ONC201 triggers an apoptotic cellular stress response in both solid and blood tumors.
- ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
ONC201 triggers an apoptotic cellular stress response in both solid and blood tumors.
- TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
Blocking TGF-β signaling in natural killer cells enhances their metabolism and ability to kill tumor cells.
Editors' Choice
- Interfering with interferons
Sphingosine 1-phosphate receptor agonists suppress immunopathology by targeting the type I interferon receptor for degradation.
- A fibrotic trio
Signaling among macrophages, endothelial cells, and fibroblasts causes fibrosis in chronic lung injury models in mice.
- Overcoming immunotherapy resistance
PTEN deficiency in tumors suppresses immunosurveillance by increasing production of inhibitory cytokines and decreasing autophagy.
- Histone deacetylase fate switch
Histone deacetylase 3 promotes the expression of oligodendrocyte-specific genes and represses the expression of astrocyte-specific genes.
- Papers of note in Science Translational Medicine
This week’s articles feature the use of nanoparticles containing a kinase inhibitor in cancer, causes of dermatitis, and a target for chronic pain.
- Papers of note in Science
This week’s articles feature insights into the regulation of cellular metabolism, regulation of transcription, and regulation of the immune system.
Focus
- ONC201: Stressing tumors to death
Two studies find that the small molecule ONC201 induces cancer cell death through cellular stress–related pathways.
About The Cover
Online Cover This week features a Focus Issue highlighting articles in this issue and the archives that describe how understanding cellular regulatory processes, such as endocytosis and protein homeostasis, enables the development of new cancer therapeutic strategies. [Image: Lightspring/Shutterstock]