Research ArticlePharmacology
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
- C. Leah B. Kline1,2,*,
- A. Pieter J. Van den Heuvel1,*,†,
- Joshua E. Allen1,3,
- Varun V. Prabhu1,2,
- David T. Dicker1,2, and
- Wafik S. El-Deiry1,2,‡
- 1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
- 2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
- 3Oncoceutics Inc., Hummelstown, PA 17036, USA.
- ↵‡Corresponding author. E-mail: wafik.eldeiry{at}fccc.edu
↵* These authors contributed equally to the work.
↵† Present address: Vironika LLC, Philadelphia, PA 19104, USA.
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Science Signaling 16 Feb 2016:
Vol. 9, Issue 415, pp. ra18
DOI: 10.1126/scisignal.aac4374