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vol. 9 no. 415 ra18
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History:
- Received April 27, 2015
- Accepted January 28, 2016
- .
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Copyright © 2016, American Association for the Advancement of Science
Research ArticlePharmacology
ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases
- C. Leah B. Kline1,2,*,
- A. Pieter J. Van den Heuvel1,*,†,
- Joshua E. Allen1,3,
- Varun V. Prabhu1,2,
- David T. Dicker1,2, and
- Wafik S. El-Deiry1,2,‡
- 1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
- 2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
- 3Oncoceutics Inc., Hummelstown, PA 17036, USA.
- ↵‡Corresponding author. E-mail: wafik.eldeiry{at}fccc.edu
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Science Signaling 16 Feb 2016:
Vol. 9, Issue 415, pp. ra18
DOI: 10.1126/scisignal.aac4374
Vol. 9, Issue 415, pp. ra18
DOI: 10.1126/scisignal.aac4374
C. Leah B. Kline
1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
A. Pieter J. Van den Heuvel
1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
Joshua E. Allen
1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
3Oncoceutics Inc., Hummelstown, PA 17036, USA.
Varun V. Prabhu
1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
David T. Dicker
1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Wafik S. El-Deiry
1Hematology/Oncology Division and Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
2Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
