Contents
23 February 2016
Vol 9, Issue 416
Vol 9, Issue 416
Contents
Research Articles
- Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses
A proangiogenic factor triggers proliferation or migration in endothelial cells by stimulating different calcium signaling patterns.
- Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis
The disaccharide trehalose blocks glucose uptake in hepatocytes and induces autophagy that prevents fatty liver disease.
- Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ
Opposing effects of Gi protein α and βγ subunits on the abundance of the second messenger cAMP enable neutrophil migration.
Podcast
- Science Signaling Podcast for 23 February 2016: G proteins in neutrophil migration
The heterotrimeric G protein subunits Gαi and Gβγ make distinct contributions to neutrophil migration.
Editors' Choice
- lncRNAs promote gene expression, too
GAL lncRNAs in yeast induce gene transcription by enabling gene looping through the formation of RNA-DNA hybrids.
- Bacteria give that full feeling
Peptides produced by stationary phase bacteria trigger satiety signals.
- Epidermal signals confine dendrites
Intercellular signaling from the epidermis maintains proper dendritic patterning in Drosophila sensory neurons.
- NEK7 activates NLRP3
A kinase that mediates mitosis is required for activation of the NLRP3 inflammasome.
- Paper of note in Science Translational Medicine
This week’s article describes a long noncoding RNA that contributes to heart disease.
- Papers of note in Science
This week’s articles feature insights into glial development, two ways calcium channels contribute to neuronal plasticity, signals that prevent T cells from reacting to food, how the microbiome supports development, and how the proteasome is regulated.
- New connections: Interpreting calcium signals
Single-cell and computational analysis reveals how cells decode calcium signals.
Focus
- Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport
Trehalose may be a silver bullet in the therapeutic arsenal against proteostasis and metabolic disorders.
About The Cover
Online Cover This week features a Research Article that describes how a proangiogenic factor triggers proliferation or migration in endothelial cells by stimulating different calcium signaling patterns. The images show calcium signals in endothelial cells during angiogenic sprout formation in a zebrafish embryo. [Image: David Noren, Daniel Wagner, and Aryeh Warmflash/Department of Biomedical Engineering, Johns Hopkins University School of Medicine and Departments of Bioengineering and BioSciences, Rice University]