Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport

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Science Signaling  23 Feb 2016:
Vol. 9, Issue 416, pp. fs2
DOI: 10.1126/scisignal.aaf1937


Although vertebrates cannot synthesize the natural disaccharide trehalose, exogenous administration of trehalose to mammalian cells may be beneficial for protein misfolding disorders. In this issue, DeBosch et al. show that trehalose may also be useful in treating nonalcoholic fatty liver disease and identify inhibition of cellular glucose import through SLC2A (also known as GLUT) transporters as a mechanism by which trehalose stimulates autophagy through the adenosine monophosphate–activated protein kinase (AMPK).

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