PodcastCell Migration

Science Signaling Podcast for 23 February 2016: G proteins in neutrophil migration

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Science Signaling  23 Feb 2016:
Vol. 9, Issue 416, pp. pc5
DOI: 10.1126/scisignal.aaf4414

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This Podcast features an interview with Alan Smrcka, author of a Research Article that appears in the 23 February 2016 issue of Science Signaling, about how different G protein subunits contribute to neutrophil migration. Neutrophils migrate to sites of inflammation by following chemical cues that activate transmembrane G protein–coupled receptors (GPCRs). Activation of these receptors causes dissociation of intracellular heterotrimeric G proteins, thus releasing Gαi and Gβγ. Both Gα and Gβγ have signaling activities. Whereas the functions of Gβγ have been described, it has been unclear whether or how Gαi contributes to chemotaxis. Surve et al. used a small molecule that activates Gβγ signaling, but does not activates Gαi signaling, to investigate how Gαi contributes to neutrophil migration. Gαi was required for cells to polarize in a chemotactic gradient and for balancing the adhesive signaling induced by Gβγ.

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