Research ArticleVASCULAR BIOLOGY Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses David P. Noren1,2, Wesley H. Chou3, Sung Hoon Lee4, Amina A. Qutub2, Aryeh Warmflash2,3, Daniel S. Wagner3, Aleksander S. Popel1,*, and Andre Levchenko4,*1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.3Department of Biosciences, Rice University, Houston, TX 77005, USA.4Yale Systems Biology Institute and Department of Biomedical Engineering, Yale University, 850 West Campus Drive, West Haven, CT 06516, USA.↵*Corresponding author. E-mail: andre.levchenko{at}yale.edu (A.L.); apopel{at}jhu.edu (A.S.P.) See allHide authors and affiliations Science Signaling 23 Feb 2016:Vol. 9, Issue 416, pp. ra20DOI: 10.1126/scisignal.aad3188 David P. Noren 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Wesley H. Chou 3Department of Biosciences, Rice University, Houston, TX 77005, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sung Hoon Lee 4Yale Systems Biology Institute and Department of Biomedical Engineering, Yale University, 850 West Campus Drive, West Haven, CT 06516, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Amina A. Qutub 2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Aryeh Warmflash 2Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, USA.3Department of Biosciences, Rice University, Houston, TX 77005, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Daniel S. Wagner 3Department of Biosciences, Rice University, Houston, TX 77005, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Aleksander S. Popel 1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: andre.levchenko@yale.edu apopel@jhu.edu Andre Levchenko 4Yale Systems Biology Institute and Department of Biomedical Engineering, Yale University, 850 West Campus Drive, West Haven, CT 06516, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: andre.levchenko@yale.edu apopel@jhu.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 9 no. 416 ra20 DOI: https://doi.org/10.1126/scisignal.aad3188 PubMed: 26905425 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received August 28, 2015Accepted January 29, 2016 . Copyright & Usage: Copyright © 2016, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: February 2016 to February 2021 AbstractFullPdf Feb 20164341224373 Mar 2016106478166 Apr 20162483055 May 20162251229 Jun 20161631927 Jul 20161581724 Aug 20161311519 Sep 20161151832 Oct 20161541924 Nov 20161291826 Dec 20161111013 Jan 2017129109 Feb 2017114918 Mar 20171001425 Apr 201786117 May 2017121523 Jun 2017101127 Jul 20177778 Aug 2017113129 Sep 20171131514 Oct 20171142222 Nov 20171391714 Dec 2017981012 Jan 201895911 Feb 2018103912 Mar 2018921327 Apr 2018822238 May 2018772841 Jun 2018632437 Jul 2018603122 Aug 201809227 Sep 2018013723 Oct 20180314149 Nov 2018027921 Dec 2018020517 Jan 20191118416 Feb 20192114425 Mar 2019188623 Apr 2019184721 May 2019215026 Jun 2019174722 Jul 201992921 Aug 2019123418 Sep 2019101415 Oct 2019122913 Nov 2019122510 Dec 2019183811 Jan 2020104414 Feb 2020163010 Mar 202094520 Apr 202013204 May 2020133418 Jun 202092619 Jul 2020164532 Aug 202084529 Sep 202044420 Oct 202075113 Nov 202043714 Dec 202063118 Jan 202163422 Feb 20214158 View Full Text
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses By David P. Noren, Wesley H. Chou, Sung Hoon Lee, Amina A. Qutub, Aryeh Warmflash, Daniel S. Wagner, Aleksander S. Popel, Andre Levchenko Science Signaling23 Feb 2016 : ra20 A proangiogenic factor triggers proliferation or migration in endothelial cells by stimulating different calcium signaling patterns. Supplementary Materials
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses By David P. Noren, Wesley H. Chou, Sung Hoon Lee, Amina A. Qutub, Aryeh Warmflash, Daniel S. Wagner, Aleksander S. Popel, Andre Levchenko Science Signaling23 Feb 2016 : ra20 A proangiogenic factor triggers proliferation or migration in endothelial cells by stimulating different calcium signaling patterns. Supplementary Materials