FocusCell Biology

Sterol hindrance of Orai activation

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Science Signaling  08 Mar 2016:
Vol. 9, Issue 418, pp. fs4
DOI: 10.1126/scisignal.aaf2357


Orai channels at the plasma membrane mediate store-operated Ca2+ entry in response to Ca2+ depletion of the endoplasmic reticulum. Orai channels are gated by stromal-interacting molecule proteins, which act as Ca2+ sensors, and the association of these proteins is enhanced in cholesterol-rich lipid rafts. In research published in Science Signaling, Derler et al. report that cholesterol inhibits Orai function through direct association with the channel amino terminus.

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