FocusCell Biology

Sterol hindrance of Orai activation

See allHide authors and affiliations

Science Signaling  08 Mar 2016:
Vol. 9, Issue 418, pp. fs4
DOI: 10.1126/scisignal.aaf2357


Orai channels at the plasma membrane mediate store-operated Ca2+ entry in response to Ca2+ depletion of the endoplasmic reticulum. Orai channels are gated by stromal-interacting molecule proteins, which act as Ca2+ sensors, and the association of these proteins is enhanced in cholesterol-rich lipid rafts. In research published in Science Signaling, Derler et al. report that cholesterol inhibits Orai function through direct association with the channel amino terminus.

View Full Text

Stay Connected to Science Signaling