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Abstract
How Ca2+ permeates the Orai1 channel and the mechanism by which the channel achieves high Ca2+ selectivity remain critical questions in understanding store-operated Ca2+ influx. In research published in Science Signaling, Frischauf et al. identified a Ca2+-accumulating region (CAR) in the extracellular opening of Orai1, which explains how concentrating Ca2+ at the mouth of Orai1 facilitates channel permeation and contributes to selectivity.
