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Abstract
This Podcast features an interview with Ivan Bogeski, author of a Research Article that appears in this issue of Science Signaling, about ORAI calcium (Ca2+) channels and reactive oxygen species (ROS) in monocytes. Monocytes are innate immune cells that engulf bacteria and produce ROS to kill them. The production of ROS in response to bacteria requires that Ca2+ flow into the cell through hexameric channels formed by ORAI subunits. However, some ORAI subunits are sensitive to and can be inhibited by ROS. Saul et al. found that the subunit composition of ORAI channels in monocytes changes to allow the cells to sustain calcium signaling even while they are producing ROS.
