Research ArticleCardiovascular Biology
A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction
- Sarah M. Schumacher1,2,
- Erhe Gao1,
- Maya Cohen3,
- Melissa Lieu1,2,
- J. Kurt Chuprun1,2, and
- Walter J. Koch1,2,*
- 1Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
- 2Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
- 3Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
- ↵*Corresponding author. E-mail: walter.koch{at}temple.edu
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Science Signaling 22 Mar 2016:
Vol. 9, Issue 420, pp. ra30
DOI: 10.1126/scisignal.aae0549
Vol. 9, Issue 420, pp. ra30
DOI: 10.1126/scisignal.aae0549
Sarah M. Schumacher
1Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
2Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Erhe Gao
1Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Maya Cohen
3Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Melissa Lieu
1Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
2Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
J. Kurt Chuprun
1Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
2Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
Walter J. Koch
1Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
2Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA.
