Editors' ChoiceInflammation

Papers of note in Science Translational Medicine

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Science Signaling  29 Mar 2016:
Vol. 9, Issue 421, pp. ec74
DOI: 10.1126/scisignal.aaf7590


A glucose balancing act

ROS deficiency promotes proinflammatory T cells in rheumatoid arthritis.

Z. Yang, Y. Shen, H. Oishi, E. L. Matteson, L. Tian, J. J. Goronzy, C. M. Weyand,

Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in

rheumatoid arthritis. Sci. Transl. Med. 8, 331ra38 (2016). [Abstract]

G. C. Tsokos, Metabolic control of arthritis: Switch pathways to treat. Sci. Transl. Med. 8, 331fs8 (2016). [Abstract]


Looping in myeloid-derived suppressor cells

MDSCs promote TH17 differentiation and systemic lupus erythematosus via arginase-1 production in patients and humanized mice.

H. Wu, Y. Zhen, Z. Ma, H. Li, J. Yu, Z.-G. Xu, X.-Y. Wang, H. Yi, Y.-G. Yang, Arginase-1–dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus. Sci. Transl. Med. 8, 331ra40 (2016). [Abstract]


Targeting protein dyshomeostasis in myopathy

Augmenting the heat shock response with arimoclomol ameliorates pathology in cellular and animal models of inclusion body myositis.

M. Ahmed, P. M. Machado, A. Miller, C. Spicer, L. Herbelin, J. He, J. Noel, Y. Wang, A. L. McVey, M. Pasnoor, P. Gallagher, J. Statland, C.-H. Lu, B. Kalmar, S. Brady, H. Sethi, G. Samandouras, M. Parton, J. L. Holton, A. Weston, L. Collinson, J. P. Taylor, G. Schiavo, M. G. Hanna, R. J. Barohn, M. M. Dimachkie, L. Greensmith, Targeting protein homeostasis in sporadic inclusion body myositis. Sci. Transl. Med. 8, 331ra41 (2016). [Abstract]