Editors' ChoiceMolecular and Cellular Biology

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Science Signaling  29 Mar 2016:
Vol. 9, Issue 421, pp. ec75
DOI: 10.1126/scisignal.aaf7550


The spread of bad neighborhoods

Disrupting the boundaries between three-dimensional neighborhoods in the genome can activate cancer-promoting genes.

D. Hnisz, A. S. Weintraub, D. S. Day, A.-L. Valton, R. O. Bak, C. H. Li, J. Goldmann, B. R. Lajoie, Z. P. Fan, A. A. Sigova, J. Reddy, D. Borges-Rivera, T. I. Lee, R. Jaenisch, M. H. Porteus, J. Dekker, R. A. Young, Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science 351, 1454–1458 (2016).[Abstract]

J. Wala, R. Beroukhim, The oncogene makes its escape. Science 351, 1398–1399 (2016). [Abstract]


The cellular ancestry of tumor antigens

Analysis of the cellular ancestry of tumor neoantigens can predict which are most likely to induce an immune response.

N. McGranahan, A. J. S. Furness, R. Rosenthal, S. Ramskov, R. Lyngaa, S. K. Saini, M. Jamal-Hanjani, G. A. Wilson, N. J. Birkbak, C. T. Hiley, T. B. K. Watkins, S. Shafi, N. Murugaesu, R. Mitter, A. U. Akarca, J. Linares, T. Marafioti, J. Y. Henry, E. M. Van Allen, D. Miao, B. Schilling, D. Schadendorf, L. A. Garraway, V. Makarov, N. A. Rizvi, A. Snyder, M. D. Hellmann, T. Merghoub, J. D. Wolchok, S. A. Shukla, C. J. Wu, K. S. Peggs, T. A. Chan, S. R. Hadrup, S. A. Quezada, C. Swanton, Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade. Science 351, 1463–1469 (2016). [Abstract]


Tracking neuronal transcriptional programs

In vivo fluorescence labeling reveals neuron-specific primordial transcriptional programs as they dynamically unfold.

L. Telley, S. Govindan, J. Prados, I. Stevant, S. Nef, E. Dermitzakis, A. Dayer, D. Jabaudon, Sequential transcriptional waves direct the differentiation of newborn neurons in the mouse neocortex. Science 351, 1443–1446 (2016). [Abstract]


Variation and transcription factor binding

The functional consequences of amino acid substitutions in transcription factors that bind to DNA are predicted and verified.

L. A. Barrera, A. Vedenko, J. V. Kurland, J. M. Rogers, S. S. Gisselbrecht, E. J. Rossin, J. Woodard, L. Mariani, K. H. Kock, S. Inukai, T. Siggers, L. Shokri, R. Gordân, N. Sahni, C. Cotsapas, T. Hao, S. Yi, M. Kellis, M. J. Daly, M. Vidal, D. E. Hill, M. L. Bulyk, Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351, 1450–1454 (2016). [Abstract]