Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

Kristopher T. Kahle; Jean-François Schmouth; Valérie Lavastre; Alban Latremoliere; Jinwei Zhang; Nick Andrews; Takao Omura; Janet Laganière; Daniel Rochefort; Pascale Hince; Geneviève Castonguay; Rébecca Gaudet; Josiane C. S. Mapplebeck; Susana G. Sotocinal; JingJing Duan; Catherine Ward; Arjun R. Khanna; Jeffrey S. Mogil; Patrick A. Dion; Clifford J. Woolf; Perrine Inquimbert; Guy A. Rouleau

doi:10.1126/scisignal.aad0163

Research ArticlePain

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

Kristopher T. Kahle¹,²,*,†,‡,
Jean-François Schmouth³,⁴,†,
Valérie Lavastre³,⁴,†,
Alban Latremoliere⁵,
Jinwei Zhang⁶,
Nick Andrews⁵,
Takao Omura⁵,
Janet Laganière³,⁴,
Daniel Rochefort³,⁴,
Pascale Hince³,
Geneviève Castonguay³,
Rébecca Gaudet³,
Josiane C. S. Mapplebeck⁷,
Susana G. Sotocinal⁷,
JingJing Duan¹,
Catherine Ward⁵,
Arjun R. Khanna²,
Jeffrey S. Mogil⁷,
Patrick A. Dion³,⁴,
Clifford J. Woolf⁵,
Perrine Inquimbert⁸, and
Guy A. Rouleau³,⁴,*

¹Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
²Department of Neurosurgery, Boston Children’s Hospital, Boston, MA 02124, USA.
³Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
⁴Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
⁵F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
⁶MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
⁷Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.
⁸Institut des Neurosciences Cellulaires et Integratives, UPR 3212 Centre National de la Recherche Scientifique, and Universite de Strasbourg, 5 rue Blaise Pascal, F-67084 Strasbourg, France.

↵*Corresponding author. E-mail: guy.rouleau{at}mcgill.ca (G.A.R.); kristopher.kahle{at}yale.edu (K.T.K.)

↵† These authors contributed equally to this work.
↵‡ Present address: Departments of Neurosurgery, Pediatrics, and Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06511, USA.

See allHide authors and affiliations

Science Signaling 29 Mar 2016:
Vol. 9, Issue 421, pp. ra32
DOI: 10.1126/scisignal.aad0163

Kristopher T. Kahle

Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.Department of Neurosurgery, Boston Children’s Hospital, Boston, MA 02124, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: guy.rouleau@mcgill.ca kristopher.kahle@yale.edu

Jean-François Schmouth

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Valérie Lavastre

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alban Latremoliere

F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jinwei Zhang

MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Nick Andrews

F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Takao Omura

F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Janet Laganière

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Daniel Rochefort

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Pascale Hince

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Geneviève Castonguay

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rébecca Gaudet

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Josiane C. S. Mapplebeck

Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Susana G. Sotocinal

Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

JingJing Duan

Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Catherine Ward

F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Arjun R. Khanna

Department of Neurosurgery, Boston Children’s Hospital, Boston, MA 02124, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jeffrey S. Mogil

Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Patrick A. Dion

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Clifford J. Woolf

F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Perrine Inquimbert

Institut des Neurosciences Cellulaires et Integratives, UPR 3212 Centre National de la Recherche Scientifique, and Universite de Strasbourg, 5 rue Blaise Pascal, F-67084 Strasbourg, France.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Guy A. Rouleau

Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: guy.rouleau@mcgill.ca kristopher.kahle@yale.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition

Plain text

Vertical Tabs

Science Signaling

Article Tools