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Research ArticlePain
Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition
- Kristopher T. Kahle1,2,*,†,‡,
- Jean-François Schmouth3,4,†,
- Valérie Lavastre3,4,†,
- Alban Latremoliere5,
- Jinwei Zhang6,
- Nick Andrews5,
- Takao Omura5,
- Janet Laganière3,4,
- Daniel Rochefort3,4,
- Pascale Hince3,
- Geneviève Castonguay3,
- Rébecca Gaudet3,
- Josiane C. S. Mapplebeck7,
- Susana G. Sotocinal7,
- JingJing Duan1,
- Catherine Ward5,
- Arjun R. Khanna2,
- Jeffrey S. Mogil7,
- Patrick A. Dion3,4,
- Clifford J. Woolf5,
- Perrine Inquimbert8, and
- Guy A. Rouleau3,4,*
- 1Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
- 2Department of Neurosurgery, Boston Children’s Hospital, Boston, MA 02124, USA.
- 3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
- 4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
- 5F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
- 6MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
- 7Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.
- 8Institut des Neurosciences Cellulaires et Integratives, UPR 3212 Centre National de la Recherche Scientifique, and Universite de Strasbourg, 5 rue Blaise Pascal, F-67084 Strasbourg, France.
- ↵*Corresponding author. E-mail: guy.rouleau{at}mcgill.ca (G.A.R.); kristopher.kahle{at}yale.edu (K.T.K.)
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Science Signaling 29 Mar 2016:
Vol. 9, Issue 421, pp. ra32
DOI: 10.1126/scisignal.aad0163
Vol. 9, Issue 421, pp. ra32
DOI: 10.1126/scisignal.aad0163
Kristopher T. Kahle
1Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
2Department of Neurosurgery, Boston Children’s Hospital, Boston, MA 02124, USA.
Jean-François Schmouth
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
Valérie Lavastre
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
Alban Latremoliere
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Jinwei Zhang
6MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Nick Andrews
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Takao Omura
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Janet Laganière
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
Daniel Rochefort
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
Pascale Hince
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
Geneviève Castonguay
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
Rébecca Gaudet
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
Josiane C. S. Mapplebeck
7Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.
Susana G. Sotocinal
7Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.
JingJing Duan
1Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Catherine Ward
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Arjun R. Khanna
2Department of Neurosurgery, Boston Children’s Hospital, Boston, MA 02124, USA.
Jeffrey S. Mogil
7Department of Psychology and Centre for Research on Pain, McGill University, Montréal, Quebec H3A 0G1, Canada.
Patrick A. Dion
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
Clifford J. Woolf
5F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Perrine Inquimbert
8Institut des Neurosciences Cellulaires et Integratives, UPR 3212 Centre National de la Recherche Scientifique, and Universite de Strasbourg, 5 rue Blaise Pascal, F-67084 Strasbourg, France.
Guy A. Rouleau
3Montreal Neurological Institute and Hospital, McGill University, Montréal, Quebec H3A 2B4, Canada.
4Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec H3A 2B4, Canada.
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