Editors' ChoiceInflammation

Paper of note in Science Advances

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Science Signaling  05 Apr 2016:
Vol. 9, Issue 422, pp. ec83
DOI: 10.1126/scisignal.aaf7980


Cell-free DNA and adipose tissue inflammation

DNA released from obesity-induced degenerated adipocytes stimulates inflammation in adipose tissue and insulin resistance.

S. Nishimoto, D. Fukuda, Y. Higashikuni, K. Tanaka, Y. Hirata, C. Murata, J.-r. Kim-Kaneyama, F. Sato, M. Bando, S. Yagi, T. Soeki, T. Hayashi, I. Imoto, H. Sakaue, M. Shimabukuro, M. Sata, Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance. Sci. Adv. 2, e1501332 (2016). [Abstract]

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