IP3 receptors: Take four IP3 to open

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Science Signaling  05 Apr 2016:
Vol. 9, Issue 422, pp. pe1
DOI: 10.1126/scisignal.aaf6029

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Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca2+ release from the endoplasmic and sarcoplasmic reticulum. Research in Science Signaling by Alzayady et al. show that all four IP3-binding sites within the tetrameric IP3R must bind IP3 before the channel can open, which has important consequences for the distribution of both IP3 and IP3R activity within cells.

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