Contents
26 April 2016
Vol 9, Issue 425
Vol 9, Issue 425
Contents
Research Articles
- Sleep deprivation impairs memory by attenuating mTORC1-dependent protein synthesis
Sleep deprivation impairs memory formation by suppressing protein synthesis.
- Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation
Blood vessel leakiness can be induced through the co-receptor NRP1 independently of VEGFR.
- Identification of GPR83 as the receptor for the neuroendocrine peptide PEN
Functional coupling occurs between PEN-GPR83 and bigLEN-GPR171, ligand-receptor pairs implicated in feeding.
Perspective
- How Ca2+-permeable AMPA receptors, the kinase PKA, and the phosphatase PP2B are intertwined in synaptic LTP and LTD
Interplay of PKA and PP2B mediates AMPA receptor trafficking in synaptic plasticity.
Editors' Choice
- Roots respond when the iron is not
Arabidopsis thaliana DELLA proteins have a tissue-specific response to iron deficiency.
- Tackling kinase inhibitor resistance
Examining receptor and intracellular kinase dynamics at the single-cell and posttranslational levels reveals new strategies to overcome drug resistance.
- Polo kinase at the mitochondria
Phosphorylation of the mitochondrial protein Miro by Polo kinase controls mitochondrial calcium handling.
- Papers of note in Science Translational Medicine
This week’s articles describe new ways to treat sepsis and pain.
- Papers of note in Science
This week’s articles address the effects of aging on antiviral immunity, how RNA-binding proteins promote B cell quiescence, transcription factors that keep tissue-resident T cells in their place, and signaling pathways that mediate innate immune memory.
- New connections: Role of 4EBPs in controlling cell behavior
The regulation of protein synthesis by 4EBP proteins underlies memory and tumor drug resistance.
Focus
- The molecular neurobiology of the sleep-deprived, fuzzy brain
Lack of sleep prevents the brain from making new proteins that enable memory formation.
About The Cover
Online Cover This week features a Research Article that reveals why getting a good night's sleep improves memory. Sleep enables protein synthesis in neurons of the hippocampus, where memories of the day's experiences are formed and stored. [Image: JHK2303/iStockphoto.com]