Editors' ChoiceImmunology

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Science Signaling  26 Apr 2016:
Vol. 9, Issue 425, pp. ec100
DOI: 10.1126/scisignal.aaf9345


Flu immunity shows its age

How age and the innate immune system affect influenza immunity is discussed.

P. S. Pillai, R. D. Molony, K. Martinod, H. Dong, I. K. Pang, M. C. Tal, A. G. Solis, P. Bielecki, S. Mohanty, M. Trentalange, R. J. Homer, R. A. Flavell, D. D. Wagner, R. R. Montgomery, A. C. Shaw, P. Staeheli, A. Iwasaki, Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease. Science 352, 463–466 (2016). [Abstract]


Reducing the risk of rearrangement

RNA-binding proteins enforce quiescence on developing lymphocytes by suppressing cell cycle progression.

A. Galloway, A. Saveliev, S. Łukasiak, D. J. Hodson, D. Bolland, K. Balmanno, H. Ahlfors, E. Monzón-Casanova, S. C. Mannurita, L. S. Bell, S. Andrews, M. D. Díaz-Muñoz, S. J. Cook, A. Corcoran, M. Turner, RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence. Science 352, 453–459 (2016). [Abstract]


Transcription factors define tissue T cells

Tissue-dwelling lymphocyte populations share a common transcriptional signature.

L. K. Mackay, M. Minnich, N. A. M. Kragten, Y. Liao, B. Nota, C. Seillet, A. Zaid, K. Man, S. Preston, D. Freestone, A. Braun, E. Wynne-Jones, F. M. Behr, R. Stark, D. G. Pellicci, D. I. Godfrey, G. T. Belz, M. Pellegrini, T. Gebhardt, M. Busslinger, W. Shi, F. R. Carbone, R. A. W. van Lier, A. Kallies, K. P. J. M. van Gisbergen, Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes. Science 352, 459–463 (2016). [Abstract]


Training immune cells to remember

M. G. Netea, L. A. B. Joosten, E. Latz, K. H. G. Mills, G. Natoli, H. G. Stunnenberg, L. A. J. O’Neill, R. J. Xavier, Trained immunity: A program of innate immune memory in health and disease. Science 352, aaf1098 (2016). [Abstract]

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