The molecular neurobiology of the sleep-deprived, fuzzy brain

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Science Signaling  26 Apr 2016:
Vol. 9, Issue 425, pp. fs7
DOI: 10.1126/scisignal.aaf6196


  • Fig. 1 Effects of sleep deprivation on protein synthesis via disrupted mTORC1 signaling.

    Reduced mTOR/mTORC1 signaling in hippocampal neurons of sleep-deprived mice leads to decreased phosphorylation of 4EBP2, resulting in disrupted protein translation, diminished neural plasticity, and ultimately, cognitive impairment. CREDIT: P. HUEY/SCIENCE SIGNALING

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