Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

Lise Roth; Claudia Prahst; Tina Ruckdeschel; Soniya Savant; Simone Weström; Alessandro Fantin; Maria Riedel; Mélanie Héroult; Christiana Ruhrberg; Hellmut G. Augustin

doi:10.1126/scisignal.aad3812

Research ArticleVASCULAR BIOLOGY

Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

Lise Roth¹,²,
Claudia Prahst¹,*,
Tina Ruckdeschel¹,
Soniya Savant¹,†,
Simone Weström¹,‡,
Alessandro Fantin³,
Maria Riedel¹,
Mélanie Héroult¹,§,
Christiana Ruhrberg³, and
Hellmut G. Augustin¹,²,¶

¹Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.
²Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.
³UCL Institute of Ophthalmology, University College London, EC1V 9EL London, UK.

↵¶Corresponding author. Email: augustin{at}angiogenese.de

↵* Present address: Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
↵† Present address: Department of Cell and Molecular Biology, Karolinska Institute, SE-171 Stockholm, Sweden.
↵‡ Present address: Department of Medical Sciences, Uppsala Universitet, 751 05 Uppsala, Sweden.
↵§ Present address: BAYER AG, Innovation Strategy Department, 51368 Leverkusen, Germany.

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Science Signaling 26 Apr 2016:
Vol. 9, Issue 425, pp. ra42
DOI: 10.1126/scisignal.aad3812

Lise Roth

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

2Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

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Claudia Prahst

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

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Tina Ruckdeschel

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

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Soniya Savant

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

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Simone Weström

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

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Alessandro Fantin

3UCL Institute of Ophthalmology, University College London, EC1V 9EL London, UK.

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Maria Riedel

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

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Mélanie Héroult

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

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Christiana Ruhrberg

3UCL Institute of Ophthalmology, University College London, EC1V 9EL London, UK.

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Hellmut G. Augustin

1Division of Vascular Oncology and Metastasis, German Cancer Research Center (DKFZ-ZMBH Alliance), 69120 Heidelberg, Germany.

2Department of Vascular Biology and Tumor Angiogenesis (CBTM), Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

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For correspondence: augustin@angiogenese.de

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Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

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