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vol. 9 no. 425 ra43
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- Received July 21, 2015
- Accepted April 6, 2016
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Copyright © 2016, American Association for the Advancement of Science
Research ArticleGPCR SIGNALING
Identification of GPR83 as the receptor for the neuroendocrine peptide PEN
- Ivone Gomes1,
- Erin N. Bobeck1,
- Elyssa B. Margolis2,
- Achla Gupta1,
- Salvador Sierra1,
- Amanda K. Fakira1,
- Wakako Fujita1,*,
- Timo D. Müller3,4,
- Anne Müller5,
- Matthias H. Tschöp3,4,
- Gunnar Kleinau5,
- Lloyd D. Fricker6, and
- Lakshmi A. Devi1,7,†
- 1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 2Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
- 3Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
- 4Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
- 5Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin, 13125 Berlin, Germany.
- 6Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- 7Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- ↵†Corresponding author. Email: lakshmi.devi{at}mssm.edu
↵* Present address: Nagasaki University, Nagasaki 852-8523, Japan.
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Science Signaling 26 Apr 2016:
Vol. 9, Issue 425, pp. ra43
DOI: 10.1126/scisignal.aad0694
Vol. 9, Issue 425, pp. ra43
DOI: 10.1126/scisignal.aad0694
Ivone Gomes
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Erin N. Bobeck
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Elyssa B. Margolis
2Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.
Achla Gupta
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Salvador Sierra
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Amanda K. Fakira
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wakako Fujita
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Timo D. Müller
3Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
4Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Anne Müller
5Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin, 13125 Berlin, Germany.
Matthias H. Tschöp
3Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany.
4Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany.
Gunnar Kleinau
5Institut für Experimentelle Pädiatrische Endokrinologie, Charité-Universitätsmedizin, 13125 Berlin, Germany.
Lloyd D. Fricker
6Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Lakshmi A. Devi
1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
7Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
