Contents
03 May 2016
Vol 9, Issue 426
Vol 9, Issue 426
Contents
Research Articles
- PERK mediates the IRES-dependent translational activation of mRNAs encoding angiogenic growth factors after ischemic stress
PERK may promote blood vessel growth in oxygen-deprived muscles by ensuring the production of angiogenic factors.
- Notch signaling in group 3 innate lymphoid cells modulates their plasticity
The balance in the proportions of innate lymphoid cell subsets depends on signaling by the receptor Notch2.
- Transforming growth factor–β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells
Opposing signals in the tissue microenvironment balance the number of intestinal group 3 innate lymphoid cells.
Podcast
- Science Signaling Podcast for 3 May 2016: Innate lymphoid cell plasticity
Notch and TGF-β signaling control the plasticity of group 3 innate lymphoid cells.
Editors' Choice
- Acetylated tau disrupts synaptic plasticity in Alzheimer’s disease
Reducing the acetylation of tau might restore cognitive function in Alzheimer’s patients.
- Ferritin out iron with pups
A prokaryotic ubiquitin-like protein modulates the function of ferritin so that bacteria can grow under iron-limiting conditions.
- IP6 in chromosome dynamics
Structural analysis of the cohesin-regulating protein PDS5 reveals inositol hexakisphosphate as a binding partner.
- New connections: Regulating innate lymphoid cells
Studies reveal mechanisms underlying the differentiation and regulation of innate lymphoid cell subsets.
- Papers of note in Science Translational Medicine
This week’s articles describe new targets for treating bacterial infection and fragile X syndrome.
- Papers of note in Science
This week’s articles highlight advances in reproductive biology, immunology, research tools, neuroscience, and the microbiome.
About The Cover
Online Cover This week features a pair of Research Articles that characterized the heterogeneity and plasticity of group 3 innate lymphoid cells (ILC3s), which regulate immune responses and tolerance in the gut and are classified according to the presence or absence of a cell surface receptor (NCR). Chea et al. found that Notch signaling was required for the differentiation of NCR– ILC3s into NCR+ ILC3s, whereas Viant et al. showed that the cytokine TGF-β had the opposite effect. The image represents the back-and-forth transition of one ILC3 subset (yellow) to another (red). [Image: Steve Gschmeissner, Science Source]