03 May 2016
Vol 9, Issue 426

About The Cover

Cover image expansion

Online Cover This week features a pair of Research Articles that characterized the heterogeneity and plasticity of group 3 innate lymphoid cells (ILC3s), which regulate immune responses and tolerance in the gut and are classified according to the presence or absence of a cell surface receptor (NCR). Chea et al. found that Notch signaling was required for the differentiation of NCR ILC3s into NCR+ ILC3s, whereas Viant et al. showed that the cytokine TGF-β had the opposite effect. The image represents the back-and-forth transition of one ILC3 subset (yellow) to another (red). [Image: Steve Gschmeissner, Science Source]