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Research ArticleNeurodegeneration
Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer’s disease
- Stephanie I. Alfonso1,*,
- Julia A. Callender2,3,*,
- Basavaraj Hooli4,*,
- Corina E. Antal2,3,†,
- Kristina Mullin4,
- Mathew A. Sherman5,
- Sylvain E. Lesné5,
- Michael Leitges6,
- Alexandra C. Newton2,‡,
- Rudolph E. Tanzi4,‡, and
- Roberto Malinow1,‡
- 1Department of Neurosciences and Division of Biology, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
- 2Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
- 3Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
- 4Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
- 5Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
- 6Biotechnology Centre of Oslo, University of Oslo, Oslo 0317, Norway.
- ↵‡Corresponding author. Email: anewton{at}ucsd.edu (A.C.N.); tanzi{at}helix.mgh.harvard.edu (R.E.T.); rmalinow{at}ucsd.edu (R.M.)
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Science Signaling 10 May 2016:
Vol. 9, Issue 427, pp. ra47
DOI: 10.1126/scisignal.aaf6209
Vol. 9, Issue 427, pp. ra47
DOI: 10.1126/scisignal.aaf6209
Stephanie I. Alfonso
Department of Neurosciences and Division of Biology, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
Julia A. Callender
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Basavaraj Hooli
Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Corina E. Antal
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA 92093, USA.
Kristina Mullin
Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Mathew A. Sherman
Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
Sylvain E. Lesné
Department of Neuroscience, N. Bud Grossman Center for Memory Research and Care, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN 55414, USA.
Michael Leitges
Biotechnology Centre of Oslo, University of Oslo, Oslo 0317, Norway.
Alexandra C. Newton
Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
Rudolph E. Tanzi
Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Roberto Malinow
Department of Neurosciences and Division of Biology, Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA.
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