Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

Ekaterina Zvezdova; Judith Mikolajczak; Anne Garreau; Marlène Marcellin; Lise Rigal; Jan Lee; Seeyoung Choi; Gaëtan Blaize; Jérémy Argenty; Julien Familiades; Liqi Li; Anne Gonzalez de Peredo; Odile Burlet-Schiltz; Paul E. Love; Renaud Lesourne

doi:10.1126/scisignal.aad1576

Research ArticleImmunology

Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

Ekaterina Zvezdova¹,*,
Judith Mikolajczak²,³,⁴,⁵,*,
Anne Garreau²,³,⁴,⁵,
Marlène Marcellin⁶,
Lise Rigal²,³,⁴,⁵,
Jan Lee¹,
Seeyoung Choi¹,
Gaëtan Blaize²,³,⁴,⁵,
Jérémy Argenty²,³,⁴,⁵,
Julien Familiades²,³,⁴,⁵,
Liqi Li¹,
Anne Gonzalez de Peredo⁶,
Odile Burlet-Schiltz⁶,
Paul E. Love¹, and
Renaud Lesourne²,³,⁴,⁵,†

¹Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
²Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France.
³Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse F-31300, France.
⁴Centre National de la Recherche Scientifique, U5282, Toulouse F-31300, France.
⁵Université de Toulouse, Université Paul Sabatier, Toulouse F-31300, France.
⁶Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse F-31077, France.

↵†Corresponding author. Email: renaud.lesourne{at}inserm.fr

↵* These authors contributed equally to this work.

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Science Signaling 17 May 2016:
Vol. 9, Issue 428, pp. ra51
DOI: 10.1126/scisignal.aad1576

Ekaterina Zvezdova

Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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Judith Mikolajczak

Centre de Physiopathologie de Toulouse Purpan, Toulouse F-31300, France.Institut National de la Santé et de la Recherche Médicale, U1043, Toulouse F-31300, France.Centre National de la Recherche Scientifique, U5282, Toulouse F-31300, France.Université de Toulouse, Université Paul Sabatier, Toulouse F-31300, France.

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Anne Garreau

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Marlène Marcellin

Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse F-31077, France.

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Lise Rigal

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Jan Lee

Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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Seeyoung Choi

Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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Gaëtan Blaize

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Jérémy Argenty

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Julien Familiades

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Liqi Li

Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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Anne Gonzalez de Peredo

Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse F-31077, France.

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Odile Burlet-Schiltz

Institut de Pharmacologie et de Biologie Structurale, Université de Toulouse, CNRS, UPS, Toulouse F-31077, France.

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Paul E. Love

Section on Cellular and Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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Renaud Lesourne

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For correspondence: renaud.lesourne@inserm.fr

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Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

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