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Papers of note in Science Translational Medicine

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Science Signaling  24 May 2016:
Vol. 9, Issue 429, pp. ec124
DOI: 10.1126/scisignal.aag1803


Giving leukemia a SMAC

SMAC mimetics simultaneously activate two different cell death pathways in treatment-resistant ALL.

G. Brumatti, C. Ma, N. Lalaoui, N.-Y. Nguyen, M. Navarro, M. C. Tanzer, J. Richmond, M. Ghisi, J. M. Salmon, N. Silke, G. Pomilio, S. P. Glaser, E. de Valle, R. Gugasyan, M. A. Gurthridge, S. M. Condon, R. W. Johnstone, R. Lock, G. Salvesen, A. Wei, D. L. Vaux, P. G. Ekert, J. Silke, The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia. Sci. Transl. Med. 8, 339ra69 (2016). [Abstract]

S. McComb, J. Aguadé-Gorgorió, L. Harder, B. Marovca, G. Cario, C. Eckert, M. Schrappe, M. Stanulla, A. von Stackelberg, J.-P. Bourquin, B. C. Bornhauser, Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL. Sci. Transl. Med. 8, 339ra70 (2016). [Abstract]