31 May 2016
Vol 9, Issue 430

About The Cover

Cover image expansion

Online Cover This week features a Research Article and an accompanying Focus that describes how the activation of PKA in cancer cells or cardiomyocytes results in the increased expression of target genes for HIF-1, a transcription factor that enables adaptation to low oxygen conditions. The image shows the diseases in which PKA-mediated stimulation and stabilization of HIF-1 may promote adaptive and anti-inflammatory tissue responses. [Image: Katharine Sutliff/Science Signaling]