Editors' ChoiceCellular and Molecular Signaling

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Science Signaling  31 May 2016:
Vol. 9, Issue 430, pp. ec131
DOI: 10.1126/scisignal.aag2209


Genes and microbes converge in colitis

A human gut microbe uses Crohn’s disease–associated genes to promote immune tolerance in the intestine.

H. Chu, A. Khosravi, I. P. Kusumawardhani, A. H. K. Kwon, A. C. Vasconcelos, L. D. Cunha, A. E. Mayer, Y. Shen, W.-L. Wu, A. Kambal, S. R. Targan, R. J. Xavier, P. B. Ernst, D. R. Green, D. P. B. McGovern, H. W. Virgin, S. K. Mazmanian, Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science 352, 1116–1120 (2016). [Abstract]

Unwinding DNA and unleashing inflammation

Depletion or chemical inhibition of Top1 suppresses the host response against influenza and Ebola viruses, as well as bacterial products.

A. Rialdi, L. Campisi, N. Zhao, A. C. Lagda, C. Pietzsch, J. S. Y. Ho, L. Martinez-Gil, R. Fenouil, X. Chen, M. Edwards, G. Metreveli, S. Jordan, Z. Peralta, C. Munoz-Fontela, N. Bouvier, M. Merad, J. Jin, M. Weirauch, S. Heinz, C. Benner, H. van Bakel, C. Basler, A. García-Sastre, A. Bukreyev, I. Marazzi, Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science 352, aad7993 (2016). [Abstract]

S. D. Pope, R. Medzhitov, Unwinding inducible gene expression. Science 352, 1058–1059 (2016). [Abstract]


Phosphorylation cues exit from mitosis

The critical phosphorylation events that control exit from mitosis are unraveled.

K. Fujimitsu, M. Grimaldi, H. Yamano, Cyclin-dependent kinase 1–dependent activation of APC/C ubiquitin ligase. Science 352, 1121–1124 (2016). [Abstract]


Calcium signals the making of symbiosis

Calcium channels coordinate to release pulses of calcium in response to microbes to initiate plant root symbioses.

M. Charpentier, J. Sun, T. Vaz Martins, G. V. Radhakrishnan, K. Findlay, E. Soumpourou, J. Thouin, A.-A. Véry, D. Sanders, R. J. Morris, G. E. D. Oldroyd, Nuclear-localized cyclic nucleotide–gated channels mediate symbiotic calcium oscillations. Science 352, 1102–1105 (2016). [Abstract]

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