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Hydroxylation-independent HIF-1α stabilization through PKA: A new paradigm for hypoxia signaling

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Science Signaling  31 May 2016:
Vol. 9, Issue 430, pp. fs11
DOI: 10.1126/scisignal.aaf4630


In this issue of Science Signaling, Bullen et al. demonstrate that protein kinase A (PKA) phosphorylates and stimulates the transcriptional activity of hypoxia-inducible transcription factor–1α (HIF-1α). This finding may have implications in diseases processes that occur at the interface of hypoxia and inflammation, where HIF-1α stabilization can function to dampen hypoxia-driven inflammation.

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