Research ArticlePharmacology
Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake
- Jonathan H. Wardman1,*,†,
- Ivone Gomes1,*,
- Erin N. Bobeck1,*,
- Jennifer A. Stockert1,
- Abhijeet Kapoor2,
- Paola Bisignano2,
- Achla Gupta1,
- Mihaly Mezei2,
- Sanjai Kumar3,
- Marta Filizola2, and
- Lakshmi A. Devi1,‡
- 1Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 2Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- 3Department of Chemistry and Biochemistry, Queens College, Flushing, NY 11367, USA.
- ↵‡Corresponding author. Email: lakshmi.devi{at}mssm.edu
↵* These authors contributed equally to this work.
↵† Present address: Department of Neurology, Rigshospitalet, 1429 Copenhagen, Denmark.
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Science Signaling 31 May 2016:
Vol. 9, Issue 430, pp. ra55
DOI: 10.1126/scisignal.aac8035